Dr. Jason Plemel began his training in the laboratory of Dr. Wolfram Tetzlaff where he completed his Doctorate. There he investigated two separate strategies to improve white matter regeneration: transplantation of precursor cells to replace lost oligodendrocytes and cell culture to find novel targets to improve remyelination. During Dr. Plemel’s postdoctoral work he studied the contribution of microglia following myelin injury in the laboratories of Dr. Peter Stys and Dr. Wee Yong. His interdisciplinary project investigated mechanisms of how immune cells respond to primary degeneration. As well, he developed a new tool to image cell death and injury using spectral microscopy.
As a new faculty at the University of Alberta, Dr. Plemel and his laboratory are investigating how microglia play an important role in the regeneration of injured white matter, but also how microglia can induce injury to white matter during different disease conditions.